Xpress™ Human CXCR5 Over-expressing Cell Line (CT26)

Description

Xpress™ Human CXCR5 over-expressing cell line (CT26) is a genetically engineered model derived from the CT26 murine colon carcinoma cell line, developed according to customer specifications. Human CXCR5 overexpression was achieved through stable integration of the exogenous human CXCR5 gene into CT26 host cells via optimized lentiviral transduction technology, ensuring high and consistent expression levels suitable for functional studies.
Target
CXCR5 (C-X-C Motif Chemokine Receptor 5) is a G protein-coupled receptor primarily expressed on B cells and a subset of T cells, including T follicular helper (Tfh) cells. It plays a pivotal role in guiding cell migration to B-cell follicles by interacting with its ligand, CXCL13. CXCR5 has emerged as a key target in immune modulation and tumor microenvironment research, particularly in understanding lymphoid tissue organization and tumor-infiltrating Lymphocyte. AcceGen provides tailored overexpression models to facilitate studies in immuno-oncology and therapeutic antibody development.