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Xpress™ Human FGL1 Over-expressing Cell Line (MC38)

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    1

  • 75
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Home | Transfected Stable Cell Lines | Overexpression Stable Cell Lines | Xpress™ Human FGL1 Over-expressing Cell Line (MC38)
Species

Human
Cat.No

ABC-X0226C
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Product Category Transfected Stable Cell Lines
Size/Quantity

1 vial
Cell Type

Epithelial-like
Shipping Info

Dry Ice
Growth Conditions

37 °C, 5% CO₂
Source Organ

Colon
Disease

Colon Adenocarcinoma
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Overexpression Stable Cell Lines
Host Cell

MC38

Description

The FGL1 MC38 Overexpression Cell Line is a genetically engineered model derived from murine colorectal cancer MC38 cells based on customers’ requirement. FGL1 MC38 overexpression cell line is generated by stable integration of exogenous human FGL1 into MC38 host cells using our optimized transduction of lentiviral vectors. Overexpression clone is validated at gene level by qRT-PCR.
Target
FGL1 (Fibrinogen-like protein 1) acts as a major ligand of LAG-3 and contributes to immune evasion in cancers. It is a promising target in immunotherapy due to its suppressive effect on T cell function. AcceGen offers generation of stable overexpression cell lines targeting any gene of your interest. Polyclonal or monoclonal is optional based on customers’ research needs.

AcceGen Frozen Cells & Cell Lines 1 vial
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Application

  • For research use only

  • Application
  • The FGL1 MC38 Overexpression Cell Line is ideal for evaluating immune checkpoint inhibitors and understanding tumor immune escape mechanisms in preclinical murine models.

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