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Xpress™ Human MTAP Over-expressing Cell Line (LN18)

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Home | Transfected Stable Cell Lines | Overexpression Stable Cell Lines | Xpress™ Human MTAP Over-expressing Cell Line (LN18)
Species

Human
Cat.No

ABC-X0362C
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Product Category Transfected Stable Cell Lines
Size/Quantity

1 vial
Cell Type

Glioblastoma Cell
Shipping Info

Dry Ice
Growth Conditions

37 °C, 5% CO2
Source Organ

Brain
Disease

Glioblastoma
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Overexpression Stable Cell Lines
Host Cell

LN18

Description

MTAP LN18 Overexpression Cell Line is a genetically engineered model derived from selected human glioblastoma (LN18) parental cell line based on customers’ requirement. MTAP LN18 overexpression cell line is generated by stable integration of exogenous human MTAP into LN18 host cells using our optimized transduction of lentiviral vectors. Overexpression clone is validated at gene level by qRT-PCR.
Target
The MTAP gene encodes methylthioadenosine phosphorylase, an enzyme involved in the methionine salvage pathway and purine metabolism. MTAP deletion is frequently observed in cancers such as glioblastoma, pancreatic cancer, and mesothelioma, contributing to tumorigenesis and metabolic vulnerabilities. Its overexpression allows investigation of tumor suppression and synthetic lethality pathways. AcceGen offers generation of stable overexpression cell lines targeting any gene of your interest. Polyclonal or monoclonal is optional based on customers’ research needs.

AcceGen Frozen Cells & Cell Lines 1 vial
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Application

  • For research use only

  • The MTAP LN18 Overexpression Cell Line serves as a powerful tool to investigate MTAP-related metabolic regulation and drug sensitivity. This model enables mechanistic studies of purine metabolism, methylation, and targeted synthetic lethality in MTAP-deficient tumors. It is utilized for screening MTAP-replacement strategies and MTAP-co-deletion associated vulnerabilities.

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