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Xpress™ Human PVRIG Over-expressing Cell Line (CHOK1)

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Home | Transfected Stable Cell Lines | Overexpression Stable Cell Lines | Xpress™ Human PVRIG Over-expressing Cell Line (CHOK1)
Species

Human
Cat.No

ABC-X0134C
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Product Category Transfected Stable Cell Lines
Size/Quantity

1 vial
Cell Type

Epithelial
Shipping Info

Dry Ice
Growth Conditions

37 °C, 5% CO₂
Source Organ

Ovary
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Overexpression Stable Cell Lines
Host Cell

CHOK1

Description

Xpress™ Human PVRIG over-expressing cell line is a genetically engineered model derived from selected CHOK1 parental cell line based on customers’ requirement. Human PVRIG overexpression cell line is generated by stable integration of exogenous human PVRIG into CHOK1 host cells using our optimized transduction of lentiviral vectors. Overexpression clone is validated at gene level by qRT-PCR.
Target
PVRIG (Poliovirus receptor-related immunoglobulin domain-containing) is an immune checkpoint receptor that binds to PVRL2 (CD112) and negatively regulates T cell activation. It is considered a novel immune inhibitory molecule contributing to immune escape in tumors. PVRIG expression has been noted in various cancers and is a target of emerging immunotherapies. AcceGen offers generation of stable overexpression cell lines targeting any gene of your interest. Polyclonal or monoclonal is optional based on customers’ research needs.

AcceGen Frozen Cells & Cell Lines 1 vial
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Application

  • For research use only

  • The PVRIG CHOK1 Overexpression Cell Line enables in vitro characterization of PVRIG-CD112 interactions and supports the screening of blocking antibodies or small molecules for immunotherapeutic strategies.

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