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Xpress™ Human PVRL4 Over-expressing Cell Line (MC38)

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Home | Transfected Stable Cell Lines | Overexpression Stable Cell Lines | Xpress™ Human PVRL4 Over-expressing Cell Line (MC38)
Species

Human
Cat.No

ABC-X0243C
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Product Category Transfected Stable Cell Lines
Size/Quantity

1 vial
Cell Type

Epithelial-like
Shipping Info

Dry Ice
Growth Conditions

37 °C, 5% CO2
Source Organ

Colon
Disease

Colon Adenocarcinoma
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Overexpression Stable Cell Lines
Host Cell

MC38

Description

Xpress™ Human PVRL4 Overexpression Cell Line (MC38) is a genetically engineered model derived from murine colon adenocarcinoma MC38 cells based on customers’ requirement. PVRL4 MC38 overexpression cell line is generated by stable integration of exogenous human PVRL4 into MC38 host cells using our optimized transduction of lentiviral vectors. Overexpression clone is validated at gene level by qRT-PCR.
Target
PVRL4, also known as nectin-4, is a member of the immunoglobulin superfamily involved in cell-cell adhesion, particularly within epithelial tissues. It plays a crucial role in tumor proliferation and metastasis and has been identified as a therapeutic target in multiple cancers including breast and lung cancers. The protein is predominantly localized at adherens junctions.
AcceGen offers generation of stable overexpression cell lines targeting any gene of your interest. Polyclonal or monoclonal is optional based on customers’ research needs.

AcceGen Frozen Cells & Cell Lines 1 vial
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Application

  • For research use only

  • The PVRL4 MC38 Overexpression Cell Line serves as a reliable model for investigating nectin-4-mediated tumorigenesis and therapeutic interventions. It is particularly useful for antibody-based therapy screening, including development of nectin-4 targeting agents and immunotherapies such as enfortumab vedotin.

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