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Xpress™ Human RANKL Over-expressing Cell Line (HEK293)

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Home | Transfected Stable Cell Lines | Overexpression Stable Cell Lines | Xpress™ Human RANKL Over-expressing Cell Line (HEK293)
Species

Human
Cat.No

ABC-X0178C
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Product Category Transfected Stable Cell Lines
Size/Quantity

1 vial
Cell Type

Epithelial
Shipping Info

Dry Ice
Growth Conditions

37 °C, 5% CO₂
Source Organ

Kidney
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Overexpression Stable Cell Lines
Host Cell

HEK293

Description

RANKL HEK293 Overexpression Cell Line is a genetically engineered model derived from selected human embryonic kidney (HEK293) parental cell line based on customers’ requirement. RANKL HEK293 overexpression cell line is generated by stable integration of exogenous human RANKL into HEK293 host cells using our optimized transduction of lentiviral vectors. Overexpression clone is validated at gene level by qRT-PCR.
Target
The RANKL gene (TNFSF11) encodes a key regulator of bone remodeling, mediating osteoclast differentiation and activation via RANK. It is also involved in immune responses and mammary gland development. Dysregulation of RANKL is associated with osteoporosis, bone metastases, and rheumatoid arthritis. AcceGen offers generation of stable overexpression cell lines targeting any gene of your interest. Polyclonal or monoclonal is optional based on customers’ research needs.

AcceGen Frozen Cells & Cell Lines 1 vial
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Application

  • For research use only

  • The RANKL HEK293 Overexpression Cell Line facilitates studies in osteoimmunology, tumor-induced bone loss, and serves as a screening tool for anti-resorptive agents targeting RANKL signaling.

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