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Xpress™ Human TPBG Over-expressing Cell Line (HepG2)

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Home | Transfected Stable Cell Lines | Overexpression Stable Cell Lines | Xpress™ Human TPBG Over-expressing Cell Line (HepG2)
Species

Human
Cat.No

ABC-X0256C
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Product Category Transfected Stable Cell Lines
Size/Quantity

1 vial
Cell Type

Epithelial-like
Shipping Info

Dry Ice
Growth Conditions

37 °C, 5% CO2
Source Organ

Liver
Disease

Hepatoblastoma
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Overexpression Stable Cell Lines
Host Cell

HepG2

Description

Xpress™ Human TPBG Overexpression Cell Line (HepG2) is a genetically engineered model derived from selected human hepatocellular carcinoma HepG2 parental cell line based on customers’ requirement. TPBG HepG2 overexpression cell line is generated by stable integration of exogenous human TPBG into HepG2 host cells using our optimized transduction of lentiviral vectors. Overexpression clone is validated at gene level by qRT-PCR.
Target
TPBG (Trophoblast Glycoprotein), also known as 5T4, is a transmembrane protein associated with embryonic development and tumor progression. It plays a role in cell adhesion, migration, and immune modulation. Its expression is upregulated in various cancers, including hepatocellular carcinoma, and correlates with poor prognosis and metastatic potential.
AcceGen offers generation of stable overexpression cell lines targeting any gene of your interest. Polyclonal or monoclonal is optional based on customers’ research needs.

AcceGen Frozen Cells & Cell Lines 1 vial
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Application

  • For research use only

  • The TPBG HepG2 Overexpression Cell Line serves as a powerful tool to investigate TPBG-driven oncogenic mechanisms and therapeutic interventions. This model enables studies on tumor cell motility, immune evasion, and epithelial-mesenchymal transition. It is suitable for screening of 5T4-targeted therapies and antibody-based therapeutics.

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