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Xpress™ Mouse B7H4 Over-expressing Cell Line (CHOK1)

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Home | Transfected Stable Cell Lines | Overexpression Stable Cell Lines | Xpress™ Mouse B7H4 Over-expressing Cell Line (CHOK1)
Species

Mouse
Cat.No

ABC-X0400C
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Product Category Transfected Stable Cell Lines
Size/Quantity

1 vial
Cell Type

Epithelial
Shipping Info

Dry Ice
Growth Conditions

37 °C, 5% CO2
Source Organ

Ovary
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Overexpression Stable Cell Lines
Host Cell

CHOK1

Description

Mouse B7H4 CHOK1 Overexpression Cell Line is a genetically engineered model derived from selected Chinese hamster ovary (CHOK1) parental cell line based on customers’ requirement. Mouse B7H4 CHOK1 overexpression cell line is generated by stable integration of exogenous mouse B7H4 (VTCN1) into CHOK1 host cells using our optimized transduction of lentiviral vectors. Overexpression clone is validated at gene level by qRT-PCR.
Target
B7H4 (VTCN1) is an immune checkpoint molecule belonging to the B7 family that plays a negative regulatory role in T-cell-mediated immune responses. Its upregulation has been observed in various cancers, where it contributes to immune suppression and tumor escape. AcceGen offers generation of stable overexpression cell lines targeting any gene of your interest. Polyclonal or monoclonal is optional based on customers’ research needs.

AcceGen Frozen Cells & Cell Lines 1 vial
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Application

  • For research use only

  • This overexpression model is ideal for research into immune checkpoint regulation, tumor immune evasion, and immunotherapy development. It can support studies on antibody generation, pathway analysis, and evaluation of novel B7H4-targeted therapeutics in preclinical mouse-relevant models.

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