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Transfected Stable Cell Lines

Xpress™ Mouse SIRPA Over-expressing Cell Line (CHOK1)

  • For research use only

Cat No.

ABC-X0131C
Product Type

Overexpression Stable Cell Lines
Cell Type

Epithelial
Species

Mouse
Host Cell

CHOK1
Source Organ

Ovary
Disease

Normal
Storage

Liquid Nitrogen

The Mouse SIRPA Overexpression Cell Line (CHOK1) provides a powerful tool for tumor immunity research, aiding in the development of anti-CD47/SIRPA.

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  • Xpress™ Mouse SIRPA Over-expressing Cell Line (CHOK1)
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Home | Transfected Stable Cell Lines | Overexpression Stable Cell Lines | Xpress™ Mouse SIRPA Over-expressing Cell Line (CHOK1)

Description

Xpress™ Mouse SIRPA over-expressing cell line (CHOK1) is a genetically engineered model derived from selected CHOK1 parental cell line based on customers’ requirement. Mouse SIRPA overexpression cell line is generated by stable integration of exogenous mouse SIRPA gene into CHOK1 host cells using our optimized transduction of lentiviral vectors. Overexpression clone is validated at gene level by qRT-PCR.
Target
SIRPA (Signal Regulatory Protein Alpha) is a transmembrane glycoprotein that functions as an inhibitory receptor regulating immune cell activation. It is predominantly expressed on myeloid cells and mediates its effects via interaction with CD47, delivering a “don’t eat me” signal to macrophages. The SIRPA-CD47 axis is a critical immune checkpoint in tumor immune evasion and is widely studied in the context of cancer immunotherapy. The target protein localizes to the plasma membrane and is involved in ITIM-mediated signaling. AcceGen offers generation of stable overexpression cell lines targeting any gene of your interest. Polyclonal or monoclonal is optional based on customers’ research needs.

Species

Mouse
Cat.No

ABC-X0131C
Product Category

Transfected Stable Cell Lines
Size/Quantity

1 vial
Cell Type

Epithelial
Growth Mode

Adherent
Shipping Info

Dry Ice
Growth Conditions

37 °C, 5% CO₂
Source Organ

Ovary
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Overexpression Stable Cell Lines
Host Cell

CHOK1
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Application

  • The Xpress™ Mouse SIRPA over-expressing cell line (CHOK1) serves as a valuable tool for investigating the molecular mechanisms of SIRPA-CD47 signaling in immune suppression and tumor immunology. It enables functional assays for ligand-receptor binding, antibody screening, and checkpoint blockade validation. This model supports the development of anti-CD47/SIRPA therapeutic strategies, including monoclonal antibodies and fusion proteins, and is applicable in high-throughput screening platforms.

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High Viability
To succeed in cell culture
Precision and Reliability
To support a consistent result
Customization Options
Tailed to your research

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