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| Product Code | 1321-N1; 1321 N1 |
| Species | Human |
| Cat.No | ABC-TC0002 |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Cell Type | Glial |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Brain |
| Disease | Astrocytoma |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Human Brain Cancer Cell Lines |
1321N1 is a human astrocytoma cell line originally derived as a subclone of 1181N1. It was established from a 47-year-old Caucasian male and displays polygonal morphology with adherent, monolayer growth, showing glial characteristics. These cells are low-tumorigenic in nude mice but widely used in neuropharmacological studies. 1321N1 expresses M2, M3, and M5 muscarinic receptors involved in phosphoinositide signaling, forming G-protein-coupled complexes influencing smooth muscle and CNS function. Upon stimulation, they release IP3, trigger intracellular calcium waves, and induce ATP release, facilitating intercellular communication. The line also expresses classic astrocytic markers such as GFAP, vimentin, and S-100 protein. Genetically, 1321N1 is hypodiploid with chromosomal abnormalities and harbors a homozygous TP53 mutation (p.Arg213Gln) and PTEN splice site mutation (c.1026+1G>T). Additionally, mitochondrial DNA mutations disrupt respiratory complexes I and IV, increasing oxidative stress.
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1321N1 cell line is a valuable tool for studying human astrocytoma biology and key signaling pathways. Researchers utilize this cell line as a model system to investigate the toxicity of dust particles generated during molten silicomanganese (SiMn) exposure to air. Additionally, the 1321N1 cell line is employed in studying the influence of thin film morphology on human astrocytoma cell behavior in vitro. It has been instrumental in studying the Caytaxin protein expression and activity, making it an essential tool in diverse research endeavors concerning human astrocytoma and related fields.
