For research use only
| Cat No. | ABC-TC0002 |
| Product Type | Human Brain Cancer Cell Lines |
| Cell Type | Glial |
| Species | Human |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Brain |
| Disease | Astrocytoma |
| Product Code | 1321-N1; 1321 N1 |
The 1321N1 cell line is a human astrocytoma model, and widely used in neuropharmacology, receptor signaling, and glioma research applications.
1321N1 is a human astrocytoma cell line derived as a subclone of the parent line 1181N1, originally established from the brain tissue of a 47-year-old Caucasian male diagnosed with astrocytoma. The cells exhibit polygonal morphology, grow adherently in monolayer culture, and demonstrate characteristic glial features. This line expresses M2, M3, and M5 muscarinic receptors involved in phosphoinositide signaling, forming G-protein-coupled complexes that influence smooth muscle and CNS function. Upon stimulation, they release IP3, trigger intracellular calcium waves, and induce ATP release, facilitating intercellular communication. The line also expresses classic astrocytic markers such as GFAP, vimentin, and S-100 protein. Genetically, 1321N1 is hypodiploid with chromosomal abnormalities and harbors a homozygous TP53 mutation (p. Arg213Gln) and a PTEN splice site mutation (c. 1026 ⁺1G>T). Mitochondrial DNA mutations impair respiratory complexes I and IV, increasing oxidative stress. 1321N1 cells are considered low-tumorigenic in immunodeficient mice but are extensively used in neuropharmacological research, particularly for studies involving G protein-coupled receptor (GPCR) signaling.
| Product Code | 1321-N1; 1321 N1 |
| Species | Human |
| Cat.No | ABC-TC0002 |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Cell Type | Glial |
| Growth Mode | Adherent |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Brain |
| Disease | Astrocytoma |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Human Brain Cancer Cell Lines |
1321N1 cell line is a valuable tool for studying human astrocytoma biology and key signaling pathways. Researchers utilize this cell line as a model system to investigate the toxicity of dust particles generated during molten silicomanganese (SiMn) exposure to air. Additionally, the 1321N1 cell line is employed in studying the influence of thin film morphology on human astrocytoma cell behavior in vitro. It has been instrumental in studying the Caytaxin protein expression and activity, making it an essential tool in diverse research endeavors concerning human astrocytoma and related fields.
When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $200 coupon. Simply click here and submit your paper’s PubMed ID (PMID).
