For research use only
| Cat No. | ABC-TC0018 |
| Product Type | Human Kidney Cancer Cell Lines |
| Cell Type | Epithelial |
| Species | Human |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Kidney |
| Disease | Renal Cell Cancer |
| Product Code | 769P; 769-p |
Utilize 769-P clear cell adenocarcinoma line for renal cancer research, enabling morphology assessment, microvilli and desmosome analysis and drug testing.
769-P is a human renal clear cell carcinoma (ccRCC) cell line established from the primary tumor of a 63-year-old female patient. The cells present epithelial-like, globular morphology with indistinct borders, high nucleus-to-cytoplasm ratio, and exhibit microvilli and desmosomes. 769-P harbors mutations in the VHL gene and secretes elevated VEGF, consistent with a ccRCC phenotype. They form colonies in soft agar and contain a side population (SP) with enhanced tumorigenic potential. Recent studies confirm that 769-P expresses oncogenic markers such as PDLIM7 and CBX3, which influence proliferation, migration, and drug sensitivity. The cells undergo rigorous screening and isolation procedures, and are rigorously tested to ensure they are free of contamination from HIV-1, HBV, HCV, Syphilis, Mycoplasma, Fungi, Yeast, and Bacteria.
| Product Code | 769P; 769-p |
| Species | Human |
| Cat.No | ABC-TC0018 |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Cell Type | Epithelial |
| Growth Mode | Adherent |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Kidney |
| Disease | Renal Cell Cancer |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Human Kidney Cancer Cell Lines |
769-P cells are extensively used in ccRCC research to investigate microenvironment interactions, hypoxia response, angiogenesis, and therapeutic vulnerabilities. In 2025, PDLIM7 knockdown studies demonstrated reduced proliferation and migration, highlighting its regulatory role in drug resistance. CBX3 overexpression has been linked to enhanced tumorigenicity via PI3K/AKT activation. Additionally, 769-P is utilized in 3D culture systems to model drug penetration and stromal crosstalk, making it ideal for preclinical evaluation of targeted therapies.
When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $200 coupon. Simply click here and submit your paper’s PubMed ID (PMID).
