For research use only
| Cat No. | ABC-TC0021 |
| Product Type | Human Kidney Cancer Cell Lines |
| Cell Type | Epithelial |
| Species | Human |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Kidney |
| Disease | Renal Cell Cancer |
| Product Code | A.704; A704 |
Human kidney adenocarcinoma. Derived from 78-year-old male. Does not produce tumours in nude mice.
A-704 cell line is a human clear cell renal carcinoma (ccRCC) epithelial cell line established from kidney tissue obtained via nephrectomy from a 78-year-old Caucasian male patient. The cells exhibit epithelial morphology with polygonal shape and form tightly adherent monolayers in vitro, lacking any notable 3D or spheroid-like growth. Cytogenetic analysis confirms a diploid karyotype. Recent studies have noted SMEK1 overexpression and downregulation of L2HGDH and HIF-1A, indicating dysregulation in the VEGF/HIF-dependent signaling axis. A-704 is non-tumorigenic and non-metastatic in nude mice models, making it suitable for in vitro studies without xenograft risk. The cells undergo rigorous screening and isolation procedures, and are rigorously tested to ensure they are free of contamination from HIV-1, HBV, HCV, Syphilis, Mycoplasma, Fungi, Yeast, and Bacteria.
| Product Code | A.704; A704 |
| Species | Human |
| Cat.No | ABC-TC0021 |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Cell Type | Epithelial |
| Growth Mode | Adherent |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Kidney |
| Disease | Renal Cell Cancer |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Human Kidney Cancer Cell Lines |
A-704 is suited for modeling non-tumorigenic ccRCC and dissecting molecular regulators of migration and proliferation such as SMEK1. It’s also ideal for investigating hypoxia-associated metabolism in low-grade RCC, specifically alterations in L2HGDH and HIF-1A pathways. A-704 has been used in recent studies evaluating iron chelation efficiency and ABCG2/PpIX dynamics, providing insight into mitochondrial and heme metabolism in RCC cells. These traits make it useful in functional genomics, metabolic drug discovery, and tumor microenvironment research.
When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $200 coupon. Simply click here and submit your paper’s PubMed ID (PMID).
