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| Product Code | A 2058; A-2058 |
| Species | Human |
| Cat.No | ABC-TC0023 |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Cell Type | Epithelial |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Skin |
| Disease | Amelanotic Melanoma |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Human Melanoma Cell Lines |
The A2058 cell line, established from a lymph node metastasis excised from a 43-year-old male Caucasian diagnosed with malignant melanoma, exhibits distinct epithelial morphology and holds significant relevance in scientific research. These cells manifest a notably high invasive potential and demonstrate marked tumorigenicity upon transplantation into nude mice. They express critical proteins including collagen type IV collagenase, tissue inhibitor of metalloproteinase-2 (TIMP-2), and autocrine motility factor, alongside nerve growth factor (NGF) and laminin receptors. Notably, A2058 cells possess strong adhesive properties to culture surfaces, simplifying their manipulation and rendering them a stable transfection host for a wide range of experimental investigations.
Why choose A2058 from AcceGen?
The A2058 cell line from AcceGen is characterized by its exceptional quality and viability. These cells are meticulously cultured under ideal conditions and undergo stringent quality control measures, including daily monitoring for sterility to ensure the absence of bacterial and fungal contaminants. Furthermore, PCR-based analysis confirms their mycoplasma-free status, attesting to the high standards of quality assurance in their maintenance.
When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).
FOR RESEARCH USE ONLY
The A2058 cell line is a valuable tool in biomedical research, particularly for studying cellular invasion in the context of melanoma. These cells closely mimic the characteristics of primary tumors, making them highly relevant in melanoma research. Researchers utilize A2058 cells to investigate the intricate roles of nerve growth factor (NGF) and laminin receptors in melanoma invasion and metastasis. Gaining a deeper understanding of these interactions not only sheds light on tumor progression mechanisms but also holds promise for the development of targeted therapeutic strategies in melanoma management.
