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| Product Code | A 2058; A-2058 |
| Species | Human |
| Cat.No | ABC-TC0023 |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Cell Type | Epithelial |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Skin |
| Disease | Amelanotic Melanoma |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Human Melanoma Cell Lines |
The A2058 cell line is a human malignant melanoma cell line derived from a lymph node metastasis of a 43-year-old Caucasian male patient. The cells display an epithelial-like morphology and exhibit adherent growth in monolayer culture, with a doubling time of approximately 27 hours. A2058 harbors the BRAF V600D mutation, a variant within the MAPK pathway commonly implicated in melanoma. The cells express invasion-associated proteins such as type IV collagenase, tissue inhibitor of metalloproteinase-2 (TIMP-2), laminin receptors, alongside elevated levels of nerve growth factor (NGF). A2058 is highly tumorigenic and metastatic, forming robust subcutaneous tumors in nude mice. The cell line is characterized by its high invasiveness in vitro, making it a model for studying melanoma metastasis.
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The A2058 cell line is a valuable tool in melanoma research, particularly for elucidating the molecular mechanisms underlying tumor invasion and metastasis. These cells express nerve growth factor (NGF) and laminin receptors which allows researchers to explore their roles in melanoma cell migration, adhesion, and interactions with the tumor microenvironment. A2058 cells are frequently employed in drug screening assays, signal transduction studies, and the development of targeted therapeutic strategies in melanoma management. The cell line’s relevance to primary and metastatic tumor behavior also supports its use in preclinical evaluation of novel anti-melanoma compounds.
