1
Discover top-quality products tailored for scientific and medical research. Request a personalized quote today
to enhance your projects.
| Product Code | ANGMCSS |
| Species | Human |
| Cat.No | ABC-TC0045 |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Brain |
| Disease | Glioblastoma |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Human Nerve Tumors Cell Lines |
ANGM-CSS is a human glioblastoma multiforme cell line derived from a 56-year-old male. It exhibits positive staining for CD133, nestin, and vimentin proteins, with partial GFAP staining. MGMT methylation is absent. Cytogenetic analysis revealed a near-tetraploid karyotype with 88 to 91 chromosomes and additional abnormalities, including unbalanced translocations (t(6;14)(p12;q11.2), t(8;10)(q24.2;q21.1), and t(5;9)(q34;p21)). ANGM-CSS also exhibits amplification of MET and EGFR genes, observed at the mRNA level. Notably, ANGM-CSS demonstrates tumorigenicity in immunodeficient mice, and the cells obtained from xenografts maintain the original cell line’s morphology and karyotype in vitro.
Why choose ANGM-CSS from AcceGen?
The ANGM-CSS cell line features high quality and viability, maintained in a sterile environment, and handled by professional operators. It undergoes rigorous quality control measures, ensuring reliability and consistency for research and experimentation purposes.
When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).
FOR RESEARCH USE ONLY
The ANGM-CSS cell line holds significant applications as a biologically relevant model for investigating the molecular pathology of glioblastoma multiforme. It proves valuable in evaluating the efficacy of novel therapeutic drugs in vitro. The cell line is instrumental in studying epigenetic alterations in gliomagenesis and identifying novel biomarkers for the diagnosis and therapeutic targeting of brain tumors. Moreover, it plays a crucial role in the development of effective strategies to induce differentiation and apoptosis in human glioblastoma multiforme cells, offering promising avenues for advancing research and potential treatments for this aggressive form of brain cancer.
