For research use only
| Cat No. | ABC-TC0055 |
| Product Type | Rat Cancer Cell Lines |
| Cell Type | Epithelial |
| Species | Rat-Copenhagen Rats |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Skin |
| Disease | AdenoCarcinoma |
| Product Code | R-3327-AT-3.1; AT3.1; Dunning AT3.1 |
Utilize AT-3.1 cells to model prostate cancer metastasis, tumor progression, and evaluate drug response in advanced carcinoma research systems.
AT-3.1 cell line is a highly metastatic epithelial prostate carcinoma cell line derived from the Dunning R-3327 transplantable tumor system in Copenhagen rats. Originating from advanced tumors, AT-3.1 represents an androgen-unresponsive and poorly differentiated subline with aggressive in vivo behavior. The cells display loosely adherent growth with spindle to polygonal morphology and rapid proliferation in vitro. Cytogenetic analysis reveals frequent chromosomal abnormalities, including c-Myc amplification and p53 loss, consistent with aggressive prostate cancer phenotypes. Upon orthotopic or subcutaneous inoculation in syngeneic rats, AT-3.1 forms primary tumors and consistently metastasizes to lymph nodes and lungs. The cells undergo rigorous screening and isolation procedures, and are rigorously tested to ensure they are free of contamination from Mycoplasma, Fungi, Yeast, and Bacteria.
| Product Code | R-3327-AT-3.1; AT3.1; Dunning AT3.1 |
| Species | Rat-Copenhagen Rats |
| Cat.No | ABC-TC0055 |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Cell Type | Epithelial |
| Growth Mode | Adherent |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Skin |
| Disease | AdenoCarcinoma |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Rat Cancer Cell Lines |
AT-3.1 serves as a high-fidelity model for studying metastatic prostate cancer, especially castration-resistant and androgen-insensitive tumor types. Its rapid in vivo metastasis to lung and lymphatic tissues allows evaluation of metastatic mechanisms, EMT regulation, and stromal interactions. The line is also used in drug resistance studies and preclinical testing of anti-metastatic agents targeting cell migration, adhesion, and invasion. As part of the Dunning series, AT-3.1 is frequently paired with low-metastatic lines for comparative studies. Its aggressive phenotype supports genomic and transcriptomic profiling to uncover drivers of progression in advanced prostate adenocarcinoma, making it indispensable in metastatic prostate cancer research.
When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $200 coupon. Simply click here and submit your paper’s PubMed ID (PMID).
