BALB/c Mouse Brain Microvascular Endothelial Cells

Description

BALB/c Mouse Brain Microvascular Endothelial Cells (BMECs) are primary cells isolated from the cerebral cortex of BALB/c mice. These cells form the core component of the blood-brain barrier (BBB). Functionally, they maintain BBB integrity, control leukocyte trafficking, and participate in neuroinflammatory responses. Studies implicate BMEC dysfunction in pathologies like ischemic stroke, Alzheimer’s disease, and cerebral microbleeds, where inflammation disrupts tight junctions, increasing BBB permeability. Key biomarkers include constitutive CD31 expression for endothelial identification and ICAM-1 upregulation under cytokine stimulation (e.g., TNF-α, IL-1β), which mediates leukocyte adhesion in neuroinflammation. Cells maintain tight junction protein expression (e.g., claudin-5, occludin), essential for BBB integrity. As primary cells, they exhibit limited proliferative capacity. Each lot undergoes rigorous screening and isolation procedures, and is rigorously tested to ensure it is free of contamination from Mycoplasma, Fungi, Yeast, and Bacteria.