For research use only
| Cat No. | ABC-TC0073 |
| Product Type | Mouse Brain Cancer Cell Lines |
| Cell Type | Endothelial |
| Species | Mouse |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Brain |
| Disease | Endothelioma |
| Product Code | bEND.3; b.End3; Bend.3; bEnd3; BEND3; brain-derived Endothelial cells.3 |
bEnd.3 Brain Endothelial Cells express vascular markers and support modeling of the blood-brain barrier, angiogenesis, and cerebral vasculature.
bEnd. 3 is a mouse endothelial cell line originally derived from the cerebral cortex of a 6-week-old BALB/c mouse with endothelioma. These cells exhibit typical endothelial morphology and adherent growth properties. bEnd. 3 cells show upregulation of adhesion molecules such as vascular cell adhesion molecule-1 (VCAM-1), intercellular adhesion molecule-1 (ICAM-1), and E-selectin, upon cytokines and lipopolysaccharide (LPS) induction. These cells constitutively express endothelial markers such as platelet endothelial cell adhesion molecule-1 (PECAM-1/CD31), von Willebrand factor (vWF), vascular endothelial-cadherin (VE-cadherin), and vascular endothelial growth factor receptor-2 (Flk-1/KDR). bEnd. 3 cells form tight junctions, respond to inflammatory stimuli, and maintain selective permeability, making them a widely used in vitro model of the blood-brain barrier (BBB). Due to their genetic stability, ease of culture, and well-characterized properties, bEnd. 3 cells are instrumental in studying cerebrovascular inflammation, drug permeability across the BBB, and neurovascular interactions in neurological diseases.
| Product Code | bEND.3; b.End3; Bend.3; bEnd3; BEND3; brain-derived Endothelial cells.3 |
| Species | Mouse |
| Cat.No | ABC-TC0073 |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Cell Type | Endothelial |
| Growth Mode | Adherent |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Brain |
| Disease | Endothelioma |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Mouse Brain Cancer Cell Lines |
The bEnd. 3 cell line is a valuable model for both vascular biology and neuroscience research. It plays a crucial role in understanding diseases linked to the lymphatic and vascular systems, including endothelioma. Notably, these cells are particularly widely used to investigate blood-brain barrier (BBB) disruption and to assess potential therapeutic interventions targeting neurological and vascular pathologies. Additionally, their adaptability to 3D cell culture models allow researchers to simulate complex physiological conditions, enhancing the relevance of in vitro models for disease mechanism studies and drug development.
When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $200 coupon. Simply click here and submit your paper’s PubMed ID (PMID).
