Bovine Aortic Endothelial Cells

Description

Bovine Aortic Endothelial Cells (BAEC) are primary endothelial cells isolated from the intimal layer of bovine aorta tissue. BAEC are cryopreserved at early passages and require careful handling to avoid repeated freeze-thaw cycles. These cobblestone-shaped, contact-inhibited cells exhibit classical endothelial morphology and adherent growth characteristic. They express high levels of endothelial-specific markers, including CD31 (PECAM-1), von Willebrand factor (vWF), and endothelial nitric oxide synthase (eNOS). These cells contribute to vascular homeostasis by regulating vasoconstriction, angiogenesis, and inflammatory responses. BAEC are widely utilized to study endothelial dysfunction and vascular pathologies such as atherosclerosis, thrombosis, and hypertension, particularly under conditions mimicking oxidative stress or hyperglycemia conditions. Due to their robust growth and ease of transfection, BAECs also serve as a standard model in cell signaling and vascular toxicology studies.