Bovine Preadipocytes

Description

Bovine preadipocytes are fibroblast-like primary cells derived from the stromal vascular fraction (SVF) of subcutaneous or perimuscular adipose tissue in cattle. These cells possess strong proliferative potential and can effectively undergo adipogenic differentiation upon induction, characterized by lipid droplet formation and increased expression of adipogenic markers such as PPARγ, C/EBPα, FABP4, and ACC1. Moreover, they exhibit responsiveness to various regulatory cues, including BMP2, microRNAs, and All-trans retinoic acid, which modulate their adipogenic potential. These properties make bovine preadipocytes a valuable in vitro model for exploring adipogenesis, lipid metabolism pathways, and as a cellular component in the development of cultured meat scaffolding systems.

Application

• For research use only.

• Bovine preadipocytes are widely used for adipogenic differentiation assays—inducing lipid accumulation and transcription factor expression under insulin/dexamethasone/IBMX/rosiglitazone protocols. They support nutrigenomics studies (e.g., glucose, CLA) and investigation of signaling modulators like TGF‑β3, BMP2, miRNAs, and ATRA. These cells serve as testbeds for metabolic intervention, cultured‑meat scaffold integration, and understanding fat–muscle cell interactions.