For research use only
| Cat No. | ABC-TC0120 |
| Product Type | Human Colon Cancer Cell Lines |
| Cell Type | Fibroblast |
| Species | Human |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Colon |
| Disease | Normal |
| Product Code | CCD18Co; CCD18 |
Leverage CCD-18Co Human Colon Fibroblasts for gastrointestinal research, enabling fibrosis, tissue regeneration, and colon disease biology studies.
CCD-18Co is a human colon fibroblast cell line derived from normal colon tissue of a 2.5-month-old Black female infant, exhibiting spindle-shaped fibroblastic morphology and adherent monolayer growth. This line retains a diploid karyotype, typical for normal human fibroblasts and express characteristic mesenchymal markers such as vimentin and fibroblast-specific protein 1 (FSP1). Functionally, the cell line demonstrate responsiveness to cytokine stimulation, including increased prostaglandin E2 (PGE2) production and upregulated COX-2 expression upon IL-1β treatment. As a non-tumorigenic cell line, CCD-18Co serves as an important model for studying stromal cell biology, fibroblast-epithelial interactions, and fibrosis mechanisms in the colon microenvironment. The stable phenotype and responsiveness make it a validated model for studying colon fibroblast physiology, extracellular matrix (ECM) interactions, and inflammation signaling pathways.
| Product Code | CCD18Co; CCD18 |
| Species | Human |
| Cat.No | ABC-TC0120 |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Cell Type | Fibroblast |
| Growth Mode | Adherent |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Colon |
| Disease | Normal |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Human Colon Cancer Cell Lines |
CCD-18Co, a non-transformed cell line, plays a central role in cancer and inflammation research. It is commonly used as a normal control in cancer studies, particularly for delineating epithelial-stromal interactions in co-culture systems. The cell line is instrumental in modeling the tumor microenvironment, enabling analysis of fibroblast-mediated signaling and extracellular matrix (ECM) remodeling. Additionally, CCD-18Co cells serves as a valuable in vitro model for investigating pathological fibrosis and inflammatory responses in the colon, providing key insights into conditions such as colitis and colon-associated fibrotic disorders.
When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).
