For research use only
| Cat No. | ABC-TC0194 |
| Product Type | Cat Kidney Cell Lines |
| Cell Type | Epithelial |
| Species | Cat – Female, 12 Week |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Kidney |
| Disease | Normal |
| Product Code | CrFK; Crfk; NBL-CrFK; Crandell Reese Feline Kidney; CFK; Crandell Feline Kidney; CCC; Crandell’s Cat Cell |
CRFK feline kidney epithelial cells, near-diploid (2n=38), adhere well, highly susceptible to feline viruses, key model for antiviral drug studies.
CRFK (Crandell-Rees Feline Kidney) is a feline kidney epithelial cell line originally established in 1964 from the cortical renal tissue of a healthy adult domestic shorthair cat. The cells grow adherently with spindle-shaped to fusiform morphology and, despite prior classification as epithelial, display mesenchymal-like features. CRFK cells show expression of vimentin, CD29 and CD44 with absence of cytokeratin and brush-border enzyme activity. The stemline karyotype analysis reveals a near-diploid chromosome count of 38 (2n=38). CRFK cells are highly susceptibile to feline calicivirus (FCV) and other feline-specific pathogens. CRFK lacks tumorigenic potential in immunodeficient mice. Due to their permissiveness to viral replication, CRFK cells have become a a cornerstone model for studying feline viral pathogenesis and evaluating antiviral drug compounds.
| Product Code | CrFK; Crfk; NBL-CrFK; Crandell Reese Feline Kidney; CFK; Crandell Feline Kidney; CCC; Crandell’s Cat Cell |
| Species | Cat – Female, 12 Week |
| Cat.No | ABC-TC0194 |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Cell Type | Epithelial |
| Growth Mode | Adherent |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Kidney |
| Disease | Normal |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Cat Kidney Cell Lines |
CRFK cells are widely used in viral research and vaccine production. They are particularly valuable for the development of live-attenuated vaccines and biological substances, with a reduced risk of contamination by Endogenous Retroviruses (ERVs). These cells play a pivotal role in investigating the potential relationship between feline vaccines and disease outcomes. Moreover, CRFK cells are extensively used in viral infectivity assays and in studies of retrovirus biology and related vector systems. Their broad utility makes them indispensable for advancing our understanding of various viral infections and their implications for feline health.
When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $200 coupon. Simply click here and submit your paper’s PubMed ID (PMID).
