For research use only
| Cat No. | ABL-TC0757 |
| Product Type | Monkey Skin Cell Lines |
| Cell Type | Fibroblast |
| Species | Monkey |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Skin |
| Product Code | Cynom-K1; CYNOMK-1; CYNOMK1 |
Cynomolgus monkey fibroblast-like CYNOM-K1 cells, non-tumorigenic, support poliovirus replication, used in viral and nucleic acid therapeutics research.
CYNOM-K1 is a fibroblast-like cell line derived from embryonic skin tissue of the cynomolgus monkey (Macaca fascicularis), harvested at a gestational stage consistent with mid- to late-term embryogenesis. These adherent cells display typical spindle-shaped fibroblast morphology and exhibit robust proliferation in monolayer culture. CYNOM-K1 cells are non-tumorigenic and non-metastatic, as demonstrated by the absence of tumor formation in immunodeficient murine xenograft models. Their most prominent application is as a permissive substrate for the replication of attenuated Sabin strains of poliovirus types I, II, and III, making them valuable in poliovirus vaccine production and quality control. Additionally, this cell line has been employed in nucleic acid therapeutic studies, including small activating RNA (saRNA)-mediated upregulation of CEBPA, a gene encoding CCAAT/enhancer-binding protein alpha, critical in hepatic and hematopoietic differentiation. CYNOM-K1 cells are generally considered genetically stable under standard culture conditions.
| Product Code | Cynom-K1; CYNOMK-1; CYNOMK1 |
| Species | Monkey |
| Cat.No | ABL-TC0757 |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Cell Type | Fibroblast |
| Growth Mode | Adherent |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Skin |
| Biosafety Level | 2 |
| Storage | Liquid Nitrogen |
| Product Type | Monkey Skin Cell Lines |
CYNOM-K1 has broad applications in genetic and vector research. It is used to evaluate hematopoietic cell transduction efficiency via chimeric lentiviral vectors, as well as for assessing the transduction efficiencies of adeno-associated virus vectors through synthetic cell-permeable peptides. Furthermore, researchers can extract genomic DNA from CYNOM-K1, allowing analysis of historical and contemporary genetic variation. These diverse applications make CYNOM-K1 a valuable and essential tool for advancing our understanding of genetic mechanisms and gene delivery techniques.
When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).
