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| Species | Mouse |
| Cat.No | ABL-TC0172 |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Disease | Sarcoma |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Mouse Sarcoma Cell Lines |
The Engelbreth-Holm-Swarm (EHS) cell line is derived from a mouse chondrosarcoma. These EHS cells are notable for producing a high level of basement membrane (BM) components, such as laminin and type IV collagen. These BM components are widely used in labs for generate cell culture surfaces that mimic the BM structure. In addition to producing BM components, EHS cells have many necessary tools for making these parts efficiently. This includes enzymes and molecular chaperones that help with modifying proteins after they are initially created. The EHS cells also expresses of transcription factors. These factors include the likes of Gata4/Gata6, Sox7/Sox17, and Cited1/Cited2. Because of these characteristics, EHS is valuable for studying complicated cell actions and processes in research.
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The EHS cell line plays a crucial role in producing Matrigel, a reconstituted basement membrane extract abundant in laminin, growth factors, collagen, entactin/nidogen, and heparan sulfate proteoglycan. This extract serves to foster and sustain differentiated phenotypes in cell cultures, finding applications in diverse in vitro and in vivo contexts. Derived from EHS tumors, these basement membrane extracts effectively mimic the extracellular matrix, thus serving as invaluable substrates for the three-dimensional cultivation of primary tissue-derived human and mouse organoids, iPSC-derived organoids, patient-derived organoids, tumorspheres, human hepatocyte sandwich cultures, as well as in supporting feeder-free cultures of stem cells and neural progenitor cells, and facilitating angiogenesis modeling through the tube formation assay.
