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EoL-1 cell

Product Name

EoL-1 cell

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Product Code

EOL-1; EOL1; EoL-1-cell; EoL-1 cell; AML-EOL-1






1 vial

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Dry Ice


Liquid Nitrogen


EoL-1 is a human eosinophilic leukemia cell line, originally established in 1984 using peripheral blood obtained from a 33-year-old male patient who had been diagnosed with acute myeloid leukemia (AML) of the eosinophilic subtype subsequent to hypereosinophilic syndrome. These cells manifest cytological features akin to myeloblasts when cultured under standard conditions. Remarkably, EoL-1 cells exhibit the capacity for both phenotypic and functional differentiation into eosinophils. Genetically, EoL-1 cells are characterized by a KMT2A (MLL) partial tandem duplication and carry the fusion gene FIP1L1-PDGFRA.


The growth rate of EoL-1 cells is notably slow, necessitating up to five days for optimal subculture conditions. Cellular growth predominantly occurs in the form of large clusters, with confluence indicators encompassing changes in culture media color and the health status of central cells. For optimal maintenance, a cautious and minimally disruptive handling approach is advised.


Why choose EoL-1 cell from AcceGen?

EoL-1 cells from AcceGen exhibit high viability and quality, maintaining sterility and freedom from mycoplasma contamination. They have been rigorously tested and confirmed negative for EBV, HBV, HCV, HHV-8, HIV-1, HIV-2, HTLV-1/2, MLV, and SMRV. Additionally, their identity has been verified through STR analysis.

Source Organ


Recommended Medium And Supplement
Citation Guide

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The EoL-1 cell line, specializing in the eosinophilic lineage, offers a valuable in vitro platform for the comprehensive investigation of malignant eosinophilic characteristics, making it a crucial asset for unraveling various aspects of eosinophil-related diseases. Moreover, EoL-1 cells provide a reliable model for delving into the functions and regulatory mechanisms of human eosinophils. Notably, this cell line has played a pivotal role in exploring the therapeutic potential of AGS67E, an antibody-drug conjugate targeting CD37 for the treatment of B/T-cell malignancies, as well as evaluating the efficacy of anti-vascular cell adhesion molecule-1 (VCAM-1) monoclonal antibodies in mitigating asthma, as demonstrated in a murine asthma model.

Growth Conditions

37 ℃, 5% CO2

Cell Type


Growth Mode


Product Type

Human Leukemia Cell Lines

Product Image AcceGen Frozen Cells & Cell Lines 1 vial
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