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Transfected Stable Cell Lines

GCGR Reporter HEK-293 Cell Line

  • For research use only

Cat No.

ABC-RC027F
Product Type

Reporter Stable Cell Lines
Cell Type

Epithelial
Species

Human
Host Cell

HEK293
Source Organ

Kidney
Disease

Normal
Storage

Liquid Nitrogen

GCGR Reporter HEK-293 Cell Line provides sensitive glucagon receptor signaling detection for metabolic research and receptor activity studies.

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  • GCGR Reporter HEK-293 Cell Line
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Description

Glucagon Receptor (GCGR) is a 62 kDa protein activated by glucagon, belonging to the B class of G protein-coupled receptor family. GCGR is mainly expressed in the liver and kidneys. Upon activation by glucagon, GCGR binds with heterotrimeric Gs (αβγ), inducing adenylyl cyclase activation, increasing cellular cAMP levels. cAMP activates PKA, leading to phosphorylation of transcriptional gene regulatory proteins and their translocation into the nucleus.GCGR Reporter HEK-293 Cell Line is a luciferase reporter cell line constructed based on the GCGR signaling pathway. When glucagon binds with its receptor GCGR, the complex activates adenylyl cyclase, elevating cellular cAMP levels. cAMP then activates PKA, phosphorylating transcriptional gene regulatory proteins, thereby activating luciferase expression. Luciferase readings represent the activation effect of the signaling pathway, making it useful for evaluating the in vitro effects of GCGR-related drugs.

Species

Human
Cat.No

ABC-RC027F
Product Category

Transfected Stable Cell Lines
Size/Quantity

1 vial
Cell Type

Epithelial
Growth Mode

Adherent
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Source Organ

Kidney
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Reporter Stable Cell Lines
Host Cell

HEK293
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Citation

When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $200 coupon. Simply click here and submit your paper’s PubMed ID (PMID).

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To support a consistent result
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