HighQC™ CHD8+/− Induced Pluripotent Stem Cell

Description

HighQC™ CHD8+/− Induced Pluripotent Stem Cells (iPSCs) are human iPSCs generated from skin fibroblasts obtained from a typically developing male donor with a normal karyotype, in which one CHD8 allele was knocked out using CRISPR/Cas9 gene editing. These cells retain typical human pluripotent stem cell morphology, forming compact, tightly packed colonies with well-defined borders, large nuclei, minimal cytoplasm, and clonal growth under adherent culture conditions. CHD8+/− iPSCs exhibit positive expression of SSEA-4. These cells possess the capacity to differentiate into derivatives of all three germ layers—ectoderm, mesoderm, and endoderm—under directed differentiation conditions. The cells undergo rigorous screening and isolation procedures, and are rigorously tested to ensure they are free of contamination from HIV-1, HBV, HCV, Syphilis, Mycoplasma, Fungi, Yeast, and Bacteria.