HighQC Human iPSC-Derived GABAergic neurons GBA null/R159W

Description

HighQC Human iPSC-Derived GABAergic neurons GBA null/R159W are human iPSC-derived GABAergic neurons generated from a human iPSC line originally derived from adult skin fibroblasts. These cryopreserved cells provide a defined in vitro model for Parkinson’s disease, gaucher disease research involving central nervous system biology. The cells are produced through a directed differentiation protocol to support reproducible lineage-specific experimental systems. This line carries a compound heterozygous GBA genotype with one null allele and one R159W missense allele, modeling reduced glucocerebrosidase activity relevant to both Gaucher disease and GBA-associated Parkinson’s disease risk, without implying a fixed clinical phenotype. They exhibit functional characteristics of GABAergic neurons. Quality control testing includes sterility assessment and lineage characterization by protein expression and gene expression assays, where applicable. Each lot undergoes rigorous screening and isolation procedures, and is rigorously tested to ensure it is free of contamination from HIV-1, HBV, HCV, Syphilis, Mycoplasma, Fungi, Yeast, and Bacteria.