HighQC Human iPSC-Derived GABAergic neurons HTT 50CAG/WT

Description

HighQC Human iPSC-Derived GABAergic neurons HTT 50CAG/WT are human iPSC-derived GABAergic neurons generated from a human iPSC line originally derived from adult skin fibroblasts. These cryopreserved cells provide a defined in vitro model for Huntington’s disease research involving central nervous system biology. The cells are produced through a directed differentiation protocol to support reproducible lineage-specific experimental systems. This line carries a heterozygous HTT allele with an expanded 50-CAG trinucleotide repeat paired with one wild-type (WT) allele, modeling polyglutamine expansion relevant to autosomal dominant Huntington’s disease, without implying a fixed clinical phenotype. They exhibit functional characteristics of GABAergic neurons. Quality control testing includes sterility assessment and lineage characterization by protein expression and gene expression assays, where applicable. Each lot undergoes rigorous screening and isolation procedures, and is rigorously tested to ensure it is free of contamination from HIV-1, HBV, HCV, Syphilis, Mycoplasma, Fungi, Yeast, and Bacteria.