HighQC™ Human IPSC-Derived Neural Stem Cell LRRK2 G2019S HET

Description

HighQC™ Human IPSC-Derived Neural Stem Cells-LRRK2 G2019S HET are a neural stem cell line derived from human iPSCs with a heterozygous G2019S mutation introduced into the LRRK2 gene using CRISPR-Cas9 gene editing. One allele carries the mutation, while the other remains wild-type at the locus. These neural stem cells express PAX6, FOXG1, and Nestin. The G2019S variant is associated with increased kinase activity, mitochondrial abnormalities, and lysosomal dysfunction in dopaminergic neurons. These cells are valuable for studying gene dosage effects, neuronal vulnerability, and pharmacological correction of LRRK2-related phenotypes. They are suitable for in vitro modeling of disease initiation and progression. The cells undergo rigorous screening and isolation procedures, and are rigorously tested to ensure they are free of contamination from HIV-1, HBV, HCV, Syphilis, Mycoplasma, Fungi, Yeast, and Bacteria.