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HighQC™ Human IPSC-Derived Neural Stem Cell MAPT P301L HOM

  • For research use only

Cat No.

ABC-SC0073T
Product Type

Human iPSCs
Cell Type

Neural Stem Cell
Species

Human
Growth Conditions

37 ℃, 5% CO2
Source Organ

iPSC
Disease

Normal
Storage

Liquid Nitrogen

Advance HighQC™ Human IPSC-Derived Neural Stem Cell MAPT P301L HOM for tauopathy modeling, neurodegenerative disease research, and drug discovery.

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  • HighQC™ Human IPSC-Derived Neural Stem Cell MAPT P301L HOM
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Home | Stem Cells | Induced Pluripotent Stem Cells (iPSCs) | Induced pluripotent stem cell-Derived cells (iPSC-Derived cells) | HighQC™ Human IPSC-Derived Neural Stem Cell MAPT P301L HOM

Description

HighQC™ Human IPSC-Derived Neural Stem Cells-MAPT P301L HOM are a human iPSC-derived neural stem cell line with a homozygous P301L mutation (CCA>CTA) introduced into the MAPT gene using CRISPR-Cas9 gene editing. Both alleles carry the mutation. These MAPT P301L homozygous iPSC-Derived NSCs express typical markers of cortical neural stem and progenitor cells, including PAX6, FOXG1, and Nestin. The cells undergo rigorous screening and isolation procedures, and are rigorously tested to ensure they are free of contamination from HIV-1, HBV, HCV, Syphilis, Mycoplasma, Fungi, Yeast, and Bacteria.
Product Code

HighQC™ Human IPSC-Derived Neural Stem Cell MAPT P301L HOM, hIPSC-NSC-MAPT-P301L-HOM, Human IPSC Neural Stem Cells MAPT P301L Homozygous
Species

Human
Cat.No

ABC-SC0073T
Product Category

Stem Cells
Size/Quantity

1 vial
Cell Type

Neural Stem Cell
Growth Mode

Adherent
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Source Organ

iPSC
Disease

Normal
Storage

Liquid Nitrogen
Product Type

Human iPSCs

Application

  • This model carries the homozygous MAPT P301L mutation linked to progressive supranuclear palsy and frontotemporal dementia. It enables mechanistic studies of tau hyperphosphorylation, axonal transport disruption, and neuronal degeneration. It is suitable for therapeutic screening against mutant tau pathways. Its relevance to multiple tauopathies makes it a versatile tool for cross-disease comparisons of tau-mediated neurodegeneration.

Citation

When you publish your research, please cite our product as "AcceGen Biotech Cat.# XXX-0000". In return, we’ll give you a $200 coupon. Simply click here and submit your paper’s PubMed ID (PMID).

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High Viability
To succeed in cell culture
Precision and Reliability
To support a consistent result
Customization Options
Tailed to your research

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