HighQC™ Human IPSC From Fibroblast-Huntington’s Disease Like

Description

HighQC™ Human IPSC From Fibroblast-Huntington’s Disease Like is a human induced pluripotent stem cell line derived from dermal fibroblasts of a donor diagnosed with a Huntington’s Disease-Like (HDL) syndrome, a clinically similar but genetically distinct disorder from classical Huntington’s disease. The reprogramming was performed using non-integrating episomal plasmid method. The resulting iPSCs (induced pluripotent stem cells) exhibit adherent growth with a high nucleus-to-cytoplasm ratio and well-defined borders. These human iPSC cell lines maintain pluripotency for HDL syndrome neural mechanism studies. These cells retain the fundamental capacity for trilineage differentiation into cell types of the ectoderm, mesoderm, and endoderm germ layers. Core pluripotency marker SSEA-4 is expressed. The cells undergo rigorous screening and isolation procedures, and are rigorously tested to ensure they are free of contamination from HIV-1, HBV, HCV, Syphilis, Mycoplasma, Fungi, Yeast, and Bacteria.