HighQC™ Human IPSC From Fibroblast-Krabbe Disease-Galactosylceramidase

Description

HighQC™ Human IPSC From Fibroblast-Krabbe Disease-Galactosylceramidase
is a disease-specific induced pluripotent stem cell line generated from dermal fibroblasts of a donor diagnosed with Krabbe Disease (Globoid Cell Leukodystrophy), a lysosomal storage disorder caused by mutations in the GALC gene. The resulting iPSCs (induced pluripotent stem cells) exhibit adherent growth with a high nucleus-to-cytoplasm ratio. These cells maintain the fundamental pluripotent capacity for trilineage differentiation into ectoderm, mesoderm, and endoderm derivatives, harboring galactosylceramidase (GALC) deficiency traits and recapitulating in vivo neural myelin metabolism. They express the core pluripotency marker SSEA-4 and support disease modeling, mechanistic studies, and target identification for Krabbe disease. The cells undergo rigorous screening and isolation procedures, and are rigorously tested to ensure they are free of contamination from HIV-1, HBV, HCV, Syphilis, Mycoplasma, Fungi, Yeast, and Bacteria.