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HighQC™ Human IPSC From Fibroblast-Muscular Dystrophy, Duchenne Type

  • For research use only

Cat No.

ABC-SC2034
Product Type

Human iPSCs
Cell Type

Induced Pluripotent Stem Cell
Species

Human
Growth Conditions

37 ℃, 5% CO2
Source Organ

Fibroblast
Disease

Muscular Dystrophy, Duchenne Type
Storage

Liquid Nitrogen

Cell Type: iPSC; Disease: Muscular Dystrophy, Duchenne Type; DMD DYSTROPHIN; DMD.

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  • HighQC™ Human IPSC From Fibroblast-Muscular Dystrophy, Duchenne Type
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Home | Stem Cells | Induced Pluripotent Stem Cells (iPSCs) | Induced Pluripotent Stem Cells (iPSCs) | HighQC™ Human IPSC From Fibroblast-Muscular Dystrophy, Duchenne Type

Description

HighQC™ Human Induced Pluripotent Stem Cells (iPSCs) From Fibroblasts – Duchenne Muscular Dystrophy (DMD) are generated from human skin fibroblasts obtained from an individual affected by Duchenne Muscular Dystrophy, a heritable neuromuscular disorder caused by mutations in the DMD gene encoding dystrophin. These cells display tight colony boundaries, high nuclear-to-cytoplasmic ratios, and clonal growth patterns. Reprogramming was performed using Sendai virus vectors, which transiently express key human transcription factors to initiate the reprogramming process. These iPSCs exhibit pluripotency, with the ability to differentiate into all three germ layers under defined conditions, and express the pluripotency marker SSEA-4. The cells undergo rigorous screening and isolation procedures, and are rigorously tested to ensure they are free of contamination from HIV-1, HBV, HCV, Syphilis, Mycoplasma, Fungi, Yeast, and Bacteria.

Product Code

HighQC™ Human IPSC From Fibroblast-Muscular Dystrophy, Duchenne Type, HighQC™ hiPSC DMD, hiPSC-DMD, HighQC™ Human Induced Pluripotent Stem Cells From Fibroblast-Duchenne Muscular Dystrophy
Species

Human
Cat.No

ABC-SC2034
Product Category

Stem Cells
Size/Quantity

1 vial
Cell Type

Induced Pluripotent Stem Cell
Growth Mode

Adherent
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Source Organ

Fibroblast
Disease

Muscular Dystrophy, Duchenne Type
Storage

Liquid Nitrogen
Product Type

Human iPSCs
Gene Info

Gene: DMD; Mutation: EX45DEL

Application

  • HighQC™ Human iPSCs derived from fibroblasts of individuals with Duchenne Muscular Dystrophy (DMD), also named Duchenne Muscular Dystrophy iPSCs, provide a disease-relevant in vitro platform for studying dystrophin deficiency, myogenic differentiation, and muscle development mechanisms. These cells support research on DMD gene function, cytoskeletal organization, and muscle cell maturation, as well as investigations into signaling pathways and transcriptional networks involved in neuromuscular disorders. In addition, they are well suited for directed differentiation into skeletal muscle and mesodermal lineages, enabling mechanistic studies of disease-associated cellular phenotypes under controlled experimental conditions.

Citation

When you publish your research, please cite our product as "AcceGen Biotech Cat.# XXX-0000". In return, we’ll give you a $200 coupon. Simply click here and submit your paper’s PubMed ID (PMID).

Frequently Asked Questions

  • Are these cells undifferentiated and actively dividing iPSCs?

    Yes. These iPSCs are maintained in an undifferentiated, actively proliferating state. They have undergone rigorous quality testing, showing stable growth without significant spontaneous differentiation or loss of pluripotency, ensuring reproducible performance for downstream applications.

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