HighQC™ Human IPSC From Fibroblast-Werner Syndrome

Description

HighQC™ Human IPSC From Fibroblast-Werner Syndrome is a disease-specific human induced pluripotent stem cell line derived from dermal fibroblasts of a donor diagnosed with Werner Syndrome, an autosomal recessive progeroid disorder caused by mutations in the Werner RecQ helicase (WRN) gene and characterized by premature aging. The resulting iPSCs (induced pluripotent stem cells) exhibit adherent growth with a high nucleus-to-cytoplasm ratio. The cells retain pluripotency and model Werner-related aging traits. They retain the fundamental capacity for trilineage differentiation into cell types of the ectoderm, mesoderm, and endoderm germ layers. Core pluripotency marker SSEA-4 is expressed. The cells undergo rigorous screening and isolation procedures, and are rigorously tested to ensure they are free of contamination from HIV-1, HBV, HCV, Syphilis, Mycoplasma, Fungi, Yeast, and Bacteria.