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HighQC™ Human IPSC From Fibroblasts With Niemann Pick Type C-Female Donor

  • For research use only

Cat No.

ABC-SC0021T
Product Type

Human iPSCs
Cell Type

Induced Pluripotent Stem Cell
Species

Human
Growth Conditions

37 ℃, 5% CO2
Source Organ

Fibroblast
Disease

Niemann Pick Type C
Storage

Liquid Nitrogen

HighQC™ Human IPSC With Niemann Pick Type C Mutation provides a disease-specific stem cell model for NPC1-related pathogenesis and therapy development.

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  • HighQC™ Human IPSC From Fibroblasts With Niemann Pick Type C-Female Donor
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Home | Stem Cells | Induced Pluripotent Stem Cells (iPSCs) | Induced Pluripotent Stem Cells (iPSCs) | HighQC™ Human IPSC From Fibroblasts With Niemann Pick Type C-Female Donor

Description

HighQC™ Human iPSC From Fibroblasts With Niemann Pick Type C-Female Donor is an induced pluripotent stem cell line reprogrammed from fibroblasts of an 8-year-old female patient diagnosed with Niemann-Pick Type C (NPC). The cell line was generated via episomal reprogramming using a proprietary mix of vectors, containing OCT4, SOX2, KLF4, p53 antisense, and EBNA-1. The cell line was validated for pluripotency based on classical colony morphology, alkaline phosphatase expression, and robust expression of key pluripotency markers including SSEA-4. The cell line is capable of differentiating into neural stem cells and functional neurons, making it especially suited for modeling neurodegenerative aspects of NPC. The cells undergo rigorous screening and isolation procedures, and are rigorously tested to ensure they are free of contamination from HIV-1, HBV, HCV, syphilis, mycoplasma, fungi, yeast, and bacteria.

Product Code

HighQC™ Human IPSC From Fibroblasts With Niemann Pick Type C-Female Donor, Human iPSC-Fib-NPC-F, hIPSC-Fib-NPC-F, Human Female Donor iPSC Niemann Pick Fibroblasts
Species

Human
Cat.No

ABC-SC0021T
Product Category

Stem Cells
Size/Quantity

1 vial
Cell Type

Induced Pluripotent Stem Cell
Growth Mode

Adherent
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Source Organ

Fibroblast
Disease

Niemann Pick Type C
Storage

Liquid Nitrogen
Product Type

Human iPSCs

Application

  • HighQC™ Human iPSC From Fibroblasts With Niemann Pick Type C-Female Donor serves as a physiologically relevant in vitro model for studying Niemann-Pick Type C disease’s mechanisms, including disrupted cholesterol transport and lysosomal dysfunction, and candidate compounds. Furthermore, the isogenic cell line enables mechanistic studies of Niemann-Pick Type C disease’s pathogenesis and validation of genetic correction strategies targeting the NPC1/NPC2 gene, supporting target identification and therapeutic development for this lysosomal storage disorder.

Citation

When you publish your research, please cite our product as "AcceGen Biotech Cat.# XXX-0000". In return, we’ll give you a $200 coupon. Simply click here and submit your paper’s PubMed ID (PMID).

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