HighQC™ Human IPSC From Foreskin Fibroblast (Alzheimer’s Disease Patient, PSEN2, N141I)

Description

HighQC™ Human iPSC From Foreskin Fibroblasts (Alzheimer’s Disease Patient, PSEN2, N141I) is an induced pluripotent stem cell derived from foreskin fibroblasts of a donor carrying the PSEN2 N141I mutation linked to early-onset familial Alzheimer’s disease (EOFAD). These cells are generated by transducing four transcription factors, OCT3/4, SOX2, KLF4, and c-MYC, into human foreskin fibroblasts, and are clonally derived and maintained under feeder-free conditions. The resulting iPSC lines retain the disease-relevant PSEN2 N141I mutation. This cell line is designed to exploit the potential of hiPSCs as versatile disease models, providing a reliable tool to study the molecular underpinnings of Alzheimer’s disease progression. The cells undergo rigorous screening and isolation procedures, and are rigorously tested to ensure they are free of contamination from HIV-1, HBV, HCV, syphilis, mycoplasma, fungi, yeast, and bacteria.