HighQC™ Human iPSC Line (Episomal, Fibroblast)

Description

HighQC™ Human iPSC Line (Episomal, Fibroblast) is a human induced pluripotent stem cell (iPSC) line generated using episomal-based reprogramming technology. This method involves the use of episomal vectors to introduce key reprogramming factors (such as OCT4, SOX2, KLF4, and c-MYC) into fibroblasts, inducing them to revert to a pluripotent state without integrating the vectors into the host genome. The resulting iPSCs exhibit typical pluripotent characteristics, including the expression of pluripotency markers like OCT4, SOX2, NANOG, and SSEA-4, and they are capable of forming embryoid bodies in culture. The Episomal vector remains in a non-integrated state within the cell and is naturally lost after reprogramming is complete, the adverse effects of long-term expression of reprogramming factors are reduced. HighQC™ Human iPSC Line (Episomal, Fibroblast) is suitable for a variety of applications, including disease modeling, drug discovery, and cell-based therapies.

Application

• HighQC™ Human iPSC Line (Episomal, Fibroblast) is ideal for disease modeling, drug discovery, and regenerative medicine. Due to its non-integrating nature, it is widely used in gene therapy research and cell-based therapy development. Specific applications include studying genetic diseases such as cystic fibrosis and ALS, developing new antiviral drugs, or conducting regenerative research for liver and retinal diseases.