Human Parental Breast Cancer Stem Cells are mainly derived from breast cancer tissues. These cells have the potential for self-renewal and multidirectional differentiation, and are considered to be key drivers of tumorigenesis, metastasis, drug resistance and recurrence. Morphologically, they are often round or oval, relatively small in size, with a high nuclear-to-cytoplasmic ratio and prominent nucleoli. Karyotype analysis often reveals chromosomal instability. Common mutations include TP53, PIK3CA, and BRCA1/2. They express stemness markers such as Oct-4 and Nanog. They can differentiate into luminal epithelial and myoepithelial cells. These cells are particularly relevant in triple-negative breast cancer models, ideal for studying tumorigenesis and therapy resistance.
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