HighQC™ Human Induced Pluripotent Stem Cells, From Amyotrophic Lateral Sclerosis

Description

HighQC™ human induced pluripotent stem cells derived from skin fibroblasts of patients with amyotrophic lateral sclerosis (ALS). These cells exhibit a high nuclear-to-cytoplasmic ratio with prominent nucleoli and grow as compact colonies under feeder-free, adherent conditions. These cells are generated by transducing OCT4, SOX2, KLF4, and c-MYC into patient-derived skin fibroblasts using Sendai virus. They express pluripotency markers including OCT4, SSEA4. These cells exhibit self-renewal capacity and retain the full pluripotent differentiation potential into all three germ layers—ectoderm, mesoderm, and endoderm under directed differentiation protocols. Each lot undergoes rigorous screening and isolation procedures, and is rigorously tested to ensure it is free of contamination from HIV-1, HBV, HCV, syphilis, mycoplasma, fungi, yeast, and bacteria.