HighQC™ INOS Knockout Mouse Embryonic Fibroblasts

Description

HighQC™ iNOS Knockout Mouse Embryonic Fibroblasts are primary fibroblast cells isolated from embryonic tissues of genetically engineered mice lacking the inducible nitric oxide synthase (iNOS/Nos2) gene. These embryonic fibroblasts are derived from mouse embryos at mid-gestation stages and are classified as primary embryonic somatic cells. Morphologically, they display a typical fibroblast-like phenotype characterized by elongated, spindle-shaped or stellate cells. The cells express the fibroblast marker FSP1/S100A4. Functionally, iNOS-deficient MEFs retain fundamental fibroblast activities including extracellular matrix synthesis, maintenance of stromal architecture, and regulation of intercellular signaling, while exhibiting altered nitric oxide–dependent signaling pathways. The cells undergo rigorous screening and isolation procedures, and are rigorously tested to ensure they are free of contamination from Mycoplasma, Fungi, Yeast, and Bacteria.