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Stem Cells

HighQC™ Nox2/Gp-91Phox Knockout Mouse Embryonic Fibroblasts

  • For research use only

Cat No.

ABC-SC0103T
Product Type

Animal Embryonic Stem Cells
Cell Type

Fibroblast
Species

Mouse
Growth Conditions

37 ℃, 5% CO2
Source Organ

Embryo
Disease

Chronic Granulomatous Disease (CGD) model
Storage

Liquid Nitrogen

Mouse Embryonic Fibroblasts from AcceGen are isolated from tissue of pathogen-free laboratory mice.

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  • HighQC™ Nox2/Gp-91Phox Knockout Mouse Embryonic Fibroblasts
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Home | Stem Cells | Embryonic Stem (ES) Cells | HighQC™ Nox2/Gp-91Phox Knockout Mouse Embryonic Fibroblasts

Description

HighQC™ Nox2/gp91 phox Knockout Mouse Embryonic Fibroblasts are primary fibroblast cells isolated from embryonic tissues of genetically engineered mice deficient in the Nox2 gene. Morphologically, they display a typical fibroblast-like phenotype, characterized by elongated spindle-shaped or stellate cells. These cells express the fibroblast marker FSP1/S100A4. Functionally, Nox2-deficient MEFs retain fundamental fibroblast properties, including extracellular matrix synthesis, maintenance of stromal structure, and participation in intercellular signaling, but exhibit altered reactive oxygen species (ROS) generation and redox-dependent signaling pathways due to loss of NADPH oxidase activity. Repeated freezing and thawing of cells is not recommended. The cells undergo rigorous screening and isolation procedures, and are rigorously tested to ensure they are free of contamination from Mycoplasma, Fungi, Yeast, and Bacteria.

Product Code

HighQC™ Nox2/Gp-91Phox Knockout Mouse Embryonic Fibroblasts, mEF-Nox2-KO, Mouse Embryonic Fibroblasts Nox2/Gp-91Phox Knockout
Species

Mouse
Cat.No

ABC-SC0103T
Product Category

Stem Cells
Size/Quantity

1 vial
Cell Type

Fibroblast
Growth Mode

Adherent
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Source Organ

Embryo
Disease

Chronic Granulomatous Disease (CGD) model
Storage

Liquid Nitrogen
Product Type

Animal Embryonic Stem Cells
Host Cell

Mouse Embryonic Fibroblasts

Application

  • HighQC™ Nox2/gp91^phox Knockout Mouse Embryonic Fibroblasts serve as a valuable in vitro model for basic research into reactive oxygen species (ROS)–dependent signaling and redox regulation in embryonic fibroblasts. The targeted deletion of the Nox2 gene enables detailed mechanistic studies of NADPH oxidase–mediated ROS production and its impact on intracellular signaling cascades, transcriptional regulation, and cellular stress responses.

Citation

When you publish your research, please cite our product as "AcceGen Biotech Cat.# XXX-0000". In return, we’ll give you a $200 coupon. Simply click here and submit your paper’s PubMed ID (PMID).

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