Human Dermal Blood Microvascular Endothelial Cells – Neonatal

Description

Human Dermal Blood Microvascular Endothelial Cells—Neonatal (HMVEC-dBlNeo) are primary endothelial cells isolated from human neonatal foreskin tissue, specifically enriched from the blood microvasculature of healthy dermal tissue. These primary cells exhibit characteristic cobblestone monolayer morphology. Functionally, HMVEC-dBlNeo maintains critical vascular functions including angiogenesis regulation, vascular barrier integrity, leukocyte trafficking, and inflammatory response modulation, with its physiological activity closely associated with lymphatic development in newborns. Their dysfunction is implicated in neonatal microvascular disorders such as retinopathy of prematurity (ROP), diabetic microangiopathy, and tumor angiogenesis. The cells are positive for blood endothelial markers CD31, VE-cadherin (CD144), and von Willebrand Factor (vWF). As primary neonatal cells, they exhibit enhanced proliferative capacity compared to adult counterparts but retain finite in vitro expansion capacity. To preserve optimal functionality, repeated freezing and thawing should be avoided during culture. The cells undergo rigorous screening and isolation procedures, and are rigorously tested to ensure they are free of contamination from HIV-1, HBV, HCV, Syphilis, Mycoplasma, Fungi, Yeast, and Bacteria.