For research use only
| Cat No. | ABC-TC0424 |
| Product Type | Human Sarcoma Cell Lines |
| Cell Type | Epithelial |
| Species | Human |
| Growth Conditions | 37 ℃, 5% CO2 |
| Disease | Fibrosarcoma |
| Product Code | Ht-1080; HT 1080; HT1080; HT 1080.T |
The cells contain an activated N-ras oncogene.
HT-1080 is a human fibrosarcoma tumor cell line originally established from a connective tissue biopsy of a 35-year-old Caucasian male with fibrosarcoma, a malignant soft-tissue sarcoma of fibroblastic origin. The cells display an epithelial-like morphology and grow as adherent monolayers in standard culture conditions. Cytogenetic analysis shows a near-diploid karyotype with frequent chromosome abnormalities, and the line harbors an activated N-ras oncogene, a key driver in sarcoma pathobiology. Subsets of HT-1080 cells express markers associated with aggressive tumor behavior and matrix interactions, which have made it a model for studying invasion and metastatic characteristics in vitro. HT-1080 is tumorigenic in immunosuppressed mice, reinforcing its relevance as a malignant tumor model. The cells undergo rigorous screening and isolation procedures, and are rigorously tested to ensure they are free of contamination from HIV-1, HBV, HCV, Syphilis, Mycoplasma, Fungi, Yeast, and Bacteria.
| Product Code | Ht-1080; HT 1080; HT1080; HT 1080.T |
| Species | Human |
| Cat.No | ABC-TC0424 |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Cell Type | Epithelial |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Disease | Fibrosarcoma |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Human Sarcoma Cell Lines |
HT-1080 cell line serves as a versatile in vitro fibrosarcoma model widely used to investigate tumor cell proliferation, invasion, and migration mechanisms and to evaluate anticancer drug responses. Their utility in matrix metalloproteinase (MMP) regulation, extracellular matrix interaction studies, and signal transduction research facilitates exploration of mechanisms driving tumor progression and therapeutic sensitivity in soft-tissue sarcomas.
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