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Primary Cells

Human Acne Peripheral Blood Mononuclear Cells

  • For research use only

Cat No.

ABC-TC4336
Product Type

Diseased Human Peripheral Blood Mononuclear Cells
Cell Type

Mononuclear Cell
Species

Human
Growth Conditions

37 ℃, 5% CO2
Source Organ

Peripheral Blood
Disease

Acne
Storage

Liquid Nitrogen

Support Human Acne Peripheral Blood Mononuclear Cells for immune profiling, biomarker discovery, and translational research in acne pathophysiology.

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  • Human Acne Peripheral Blood Mononuclear Cells
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Home | Primary Cells | Human Primary Cells | PBMCs | Human Acne Peripheral Blood Mononuclear Cells

Description

Human Acne Peripheral Blood Mononuclear Cells (PBMCs) are isolated from patients with moderate to severe acne vulgaris, providing researchers with a critical tool to study the systemic immune response in acne pathogenesis. Acne is a chronic inflammatory skin disorder of the pilosebaceous unit. These PBMCs contain immune cell populations (T cells, B cells, NK cells, and monocytes) that reflect the chronic inflammatory state associated with acne. Morphologically, PBMCs are typically round or oval. They play a central role in acne pathogenesis by driving inflammatory responses—promoting monocyte differentiation into macrophages, secreting proinflammatory cytokines (IL-1β, TNF-α), and activating Th17 cells to release IL-17. These mechanisms contribute to both abnormal keratinization of the pilosebaceous unit and the exaggerated immune response to Propionibacterium acnes.

Product Code

Human Acne Peripheral Blood Mononuclear Cells, hAcne-PBMC, PBMCs from Acne Patients
Species

Human
Cat.No

ABC-TC4336
Product Category

Primary Cells
Size/Quantity

1 vial
Cell Type

Mononuclear Cell
Growth Mode

Adherent
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Source Organ

Peripheral Blood
Disease

Acne
Storage

Liquid Nitrogen
Product Type

Diseased Human Peripheral Blood Mononuclear Cells
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Application

  • Human Acne Peripheral Blood Mononuclear Cells can be used to explore immune regulation mechanisms, inflammatory responses, and potential therapeutic targets. In vitro experiments can be conducted to evaluate cytokine secretion (such as IL-1β, IL-6, IL-17, and TNF-α) induced by Propionibacterium acnes or other stimuli, thereby revealing key pathological processes such as Th17/Tregs imbalance and NLRP3 inflammasome activation.

Citation

When you publish your research, please cite our product as "AcceGen Biotech Cat.# XXX-0000". In return, we’ll give you a $200 coupon. Simply click here and submit your paper’s PubMed ID (PMID).

Frequently Asked Questions

  • What are mononuclear cells?

    Mononuclear cells are blood cells characterized by a single, round nucleus. In peripheral blood, they mainly include lymphocytes (T cells, B cells, and NK cells) and monocytes and play central roles in immune surveillance and inflammatory responses.

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