Human Acute Lymphoid Leukemia Peripheral Blood Mononuclear Cells (Newly Diagnosed/Untreated)

Description

Human Acute Lymphoid Leukemia (ALL) Peripheral Blood Mononuclear Cells (PBMCs)(Newly Diagnosed/Untreated) are isolated from the peripheral blood of newly diagnosed and untreated acute lymphoblastic leukemia patients. ALL is most common in children but also occurs in adults, leading to impaired normal blood cell production and immune dysfunction. These PBMCs are enriched via density gradient centrifugation and consist of lymphocytes (T cells, B cells, NK cells) and monocytes. In ALL samples, the lymphoid fraction is typically dominated by malignant lymphoblasts, which are morphologically distinct—large cells with a high nuclear-to-cytoplasmic ratio and prominent nucleoli. These cells serve as a critical ex vivo model for investigating leukemogenesis, immune dysregulation, and therapy resistance in early-stage ALL. In translational investigations, these samples enable comprehensive PBMC gene expression ALL profiling to identify novel biomarkers ALL, support ALL progression monitoring, complement routine blood tests acute lymphoid leukemia, and strengthen analyses of mononuclear cells in leukemia study within broader human leukemia cell research frameworks.