Human Adipose Microvascular Endothelial Cells (HAMVECs) are primary endothelial cells isolated from subcutaneous adipose tissue of healthy human donors. These cells exhibit a cobblestone-like morphology under standard culture conditions. Functionally, HAMVECs contribute to adipose tissue homeostasis by forming selective vascular barriers, facilitating fatty acid transcytosis, and secreting PPARγ ligands that modulate adipose tissue metabolism. They are implicated in obesity-related pathologies, including insulin resistance and chronic inflammation, through palmitate-induced activation of TLR4/NF-κB signaling pathway, which impair insulin delivery and promote monocyte adhesion. These cells express high levels of endothelial markers such as CD31, CD34, and von Willebrand factor (vWF), and exhibit depot-specific transcriptional profiles enriched in lipid-handling and Notch signaling pathways. As primary cells, HAMVECs have limited proliferative capacity, requiring low passage numbers for optimal viability and functionality.
Inquiring Human Adipose Microvascular Endothelial Cells
We know how valuable your research is to you, but are you wondering what you can expect to pay for quick accurate results every time? Fill out a request in the form below and we’ll get back to you within 24 hours with a quote.
High Viability
To succeed in cell culture
Precision and Reliability
To support a consistent result
Customization Options
Tailed to your research
