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Primary Cells

Human Adrenal Cortical Cells

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The adrenal cortex makes up the perimeter of the adrenal gland and plays an essential role in regulating homeostasis in the body through the secretion of corticosteroid and androgen hormones. The secreted steroids arise from three zones that form the adrenal gland, which provide the framework of the adrenal cortex. The cells in the cortex […]
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Home | Primary Cells | Human Primary Cells | Endocrine System Primary Cells | Human Adrenal Cortical Cells
Product Code

HAdCC
Species

Human
Cat.No

ABC-TC3477
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Product Category Primary Cells
Size/Quantity

1 vial
Cell Type

Cortical Cell
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Source Organ

Adrenal
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Adrenal Cells

Description

Human Adrenal Cortical CellsHuman Adrenal Cortical Cells are primary cells derived from pooled human fetal adrenal cortical tissue from multiple donors of mixed gender. The fetal adrenal cortex comprises two zones—the fetal and definitive zones—while the adult cortex includes the zona glomerulosa, zona fasciculata, and zona reticularis. These cells, typically grown as adherent monolayers, are organized in cord-like structures in vivo and display morphological heterogeneity, including smaller round cells in the zona glomerulosa and polyhedral cells in the fasciculata and reticularis. They actively secrete hormones, cytokines, and peptides, and express key steroidogenic enzymes such as CYP11B1, CYP17A1, and StAR. The cells interact with local immune related signals such as IL-1, IL-6, and VIP released by adrenal macrophages.

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Application

  • Human Adrenal Cortical Cells serve as a valuable model for investigating adrenal disorders like adrenal insufficiency, Cushing’s syndrome, Conn’s syndrome, and adrenocortical carcinoma. By studying these cells, researchers can uncover the molecular and biochemical mechanisms regulating adrenal steroidogenesis. This knowledge can lead to better diagnostics and targeted therapies. Moreover, human adrenal cortical cells provide a platform to explore the effects of chemicals on adrenal hormone synthesis. Researchers can assess how various compounds impact hormone production, shedding light on how external factors influence adrenal function.

Frequently Asked Questions

  • What are Human Adrenal Cortical Cells?

    Human Adrenal Cortical Cells are specialized cells located in the adrenal cortex, the outer layer of the adrenal glands. They are responsible for producing steroid hormones such as cortisol, aldosterone, and androgens.

  • What are the main functions of Human Adrenal Cortical Cells?

    The primary functions of these cells include the production and secretion of steroid hormones, which regulate a variety of physiological processes, including metabolism, immune response, blood pressure, and stress response.

  • What applications are Human Adrenal Cortical Cells used for?

    These cells are used in endocrinology research, drug development, and studies related to adrenal gland disorders such as Addison’s disease, Cushing’s syndrome, and primary aldosteronism. They are also used to study steroidogenesis and hormonal regulation.

  • Are there any specific markers used to identify Human Adrenal Cortical Cells?

    Human Adrenal Cortical Cells can be specifically identified through immunofluorescence staining for 3β-hydroxysteroid dehydrogenase (3β-HSD), an enzyme crucial in the biosynthesis of steroid hormones. 3β-HSD is expressed predominantly in adrenal cortical cells, making it an ideal marker for distinguishing these cells from others.

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