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Primary Cells

Human Adrenal Cortical Cells

  • For research use only

Cat No.

ABC-TC3477
Product Type

Adrenal Cells
Cell Type

Cortical Cell
Species

Human
Growth Conditions

37 ℃, 5% CO2
Source Organ

Adrenal
Disease

Normal
Storage

Liquid Nitrogen

Human Adrenal Cortical Cells from fetal tissue grow as monolayers, secrete hormones and cytokines, and express enzymes CYP11B1 and CYP17A1.

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  • Human Adrenal Cortical Cells
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Home | Primary Cells | Human Primary Cells | Endocrine System Primary Cells | Human Adrenal Cortical Cells

Description

Human Adrenal Cortical Cells (HACCs) are isolated from the adrenal cortex, the outer region of the adrenal glands, and are primarily responsible for the synthesis and secretion of steroid hormones. Morphologically, these cells are polygonal or cuboidal, with an eosinophilic cytoplasm containing abundant lipid droplets, reflecting their steroidogenic role. Functionally, HACCs can be divided into three zones: the zona glomerulosa secretes aldosterone (regulates electrolyte balance), the zona fasciculata secretes cortisol (regulates metabolism and stress response), and the zona reticularis produces androgens (affects sexual development). Abnormal function of these cells can lead to a variety of endocrine diseases, such as Cushing’s syndrome (excessive cortisol), Addison’s disease (adrenocortical insufficiency), and hyperaldosteronism (excessive aldosterone secretion). Overall, adrenal cortical cells are the specialized cells of the adrenal cortex that produce diverse steroid hormones in distinct adrenal cortex zones, ensuring endocrine homeostasis within the cortex of adrenal gland and the broader adrenal cortex.

Product Code

HAdCC
Species

Human
Cat.No

ABC-TC3477
Product Category

Primary Cells
Size/Quantity

1 vial
Cell Type

Cortical Cell
Growth Mode

Adherent
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Source Organ

Adrenal
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Adrenal Cells
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Application

  • Human Adrenal Cortical Cells can be used to study the physiological functions, hormone synthesis and secretion mechanisms of the adrenal cortex. Through in-depth research, we can further understand the mechanism of action of adrenal cortical hormones (such as aldosterone, cortisol, and androgen) in regulating electrolyte balance, metabolism, stress response and sexual development.

Citation

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Frequently Asked Questions

  • What are Human Adrenal Cortical Cells?

    Human Adrenal Cortical Cells are specialized cells located in the adrenal cortex, the outer layer of the adrenal glands. They are responsible for producing steroid hormones such as cortisol, aldosterone, and androgens.

  • What are the main functions of Human Adrenal Cortical Cells?

    The primary functions of these cells include the production and secretion of steroid hormones, which regulate a variety of physiological processes, including metabolism, immune response, blood pressure, and stress response.

  • What applications are Human Adrenal Cortical Cells used for?

    These cells are used in endocrinology research, drug development, and studies related to adrenal gland disorders such as Addison’s disease, Cushing’s syndrome, and primary aldosteronism. They are also used to study steroidogenesis and hormonal regulation.

  • Are there any specific markers used to identify Human Adrenal Cortical Cells?

    Human Adrenal Cortical Cells can be specifically identified through immunofluorescence staining for 3β-hydroxysteroid dehydrogenase (3β-HSD), an enzyme crucial in the biosynthesis of steroid hormones. 3β-HSD is expressed predominantly in adrenal cortical cells, making it an ideal marker for distinguishing these cells from others.

  • How is their identity validated?

    Cell identity is confirmed by histological localization during isolation and validated using cell-specific markers. Immunofluorescence staining for 3β-HSD is positive, and the cell purity exceeds 90%.

  • Can these cells be subcultured, and if so, for how many passages?

    Human adrenal cortical cells can be subcultured, with phenotypic and functional stability maintained for 2–3 passages. Excessive passaging may lead to alterations in cell morphology or functionality, so early passages are recommended for reliable experimental outcomes.

  • Where is adrenal cortex located?

    The adrenal cortex is the outer region of the adrenal gland, which is located on top of each kidney. It surrounds the adrenal medulla and is responsible for the production of steroid hormones involved in metabolism, electrolyte balance, and stress response.

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