Human Adrenal Microvascular Endothelial Cells

Description

Human Adrenal Microvascular Endothelial Cells (HAMECs) are primary cells isolated from healthy human adrenal tissue. Following primary culture, these cells are cryopreserved. These specialized endothelial cells exhibit characteristic cobblestone morphology and grow in adherent monolayers. They perform critical physiological functions within the adrenal microenvironment, including regulation of blood flow, hormone transport, vascular permeability, and angiogenesis. Their functional dysregulation is closely associated with endothelial inflammation in the adrenal glands. As a core cellular component of the adrenal vascular network, HAMECs serve as an authentic and valuable in vitro model for adrenal microcirculation research. HAMECs demonstrate unique endocrine properties, secreting vasoactive factors such as endothelin-1, nitric oxide, adrenomedullin, and proadrenomedullin N-terminal 20 peptide (PAMP), which may influence aldosterone secretion. HAMECs, unlike brain and liver MECs, are highly resistant to glucocorticoid-induced cytotoxicity. They express endothelial markers (CD31) and von Willebrand Factor (vWF). Repeated freezing and thawing should be avoided during culture. The cells undergo rigorous screening and isolation procedures, and are rigorously tested to ensure they are free of contamination from HIV-1, HBV, HCV, Syphilis, Mycoplasma, Fungi, Yeast, and Bacteria.