Human Aortic Smooth Muscle Cells-Diabetic Type II

Description

Human Aortic Smooth Muscle Cells-Diabetic Type II are primary cells isolated from human aortic tissue of clinically confirmed Type II diabetic donors. They are typically obtained and cryopreserved at early passage to maintain their disease-related characteristics. These cells exhibit characteristic spindle-shaped morphology and grow as adherent monolayers. Functionally, they contribute to the regulation of vascular tone, but in a diabetic context, their function is altered. This has been shown to be closely associated with diabetic vasculopathy, a major complication of Type II diabetes. Regarding gene expression, they express smooth muscle-specific proteins like α-smooth muscle actin. These cells have a relatively normal karyotype. Repeated freezing and thawing should be avoided during culture. The cells undergo rigorous screening and isolation procedures, and are rigorously tested to ensure they are free of contamination from HIV-1, HBV, HCV, Syphilis, Mycoplasma, Fungi, Yeast, and Bacteria.