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Human Astrocytes-Brain

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Astrocytes make up the majority of the cells in the mammalian brain. They are the most variable in type, most intimately associated with all parts of neurons, and thus most functionally interesting in their relationships with neurons. They provide structural, trophic, and metabolic support to neurons and modulate synaptic activity. Impairment of these astrocyte functions […]
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Home | Primary Cells | Human Primary Cells | Nervous System Primary Cells | Human Astrocytes-Brain
Product Code

HA
Species

Human
Cat.No

ABC-TC3969
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Product Category Primary Cells
Size/Quantity

1 vial
Cell Type

Astrocyte
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Source Organ

Brain
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Nervous Cells
Key Features

-Backed by AcceGen advanced technology
-Cryopreserved for highest viability and plating efficiency
-Quality-tested for accurate results

Description

Human Astrocytes-Brain are a type of glial cells derived from the human brain tissue. These cells can express glial fibrillary acidic protein (GFAP), a hallmark feature of astrocytes. They are also able to secrete a variety of growth factors such as TGF-β1 . Human brain astrocytes exhibit stellate morphology with multiple branching processes and adhere to culture vessels, growing in a monolayer under standard conditions.These cells play an important role in promoting neuronal survival and synapse formation. Studies have shown that there are three Ca²⁺ signaling related genes (RYR3, MRVI1, and RGN) that are enriched in human astrocytes . These genes regulate intracellular calcium dynamics, influencing astrocyte-neuron communication and neuroprotective functions. Due to their involvement in neurotrophic support, synaptic modulation, and inflammatory responses, human astrocytes serve as an essential model for studying neurodegenerative diseases, neurodevelopmental disorders, and neural repair mechanisms.

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Citation

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Application

  • Human Astrocytes-Brain can be used as an in vitro cell model to study the secretion mechanism of neurotrophic factors such as TGF-β1 and BDNF. They can also be used to study the blood-brain barrier and the pathogenesis of neurodegenerative diseases.

Frequently Asked Questions

  • What are human astrocytes, and what role do they play in the nervous system?

    Human astrocytes are star-shaped cells in the brain and spinal cord. They support neurons, maintain the blood-brain barrier, regulate blood flow, help repair injuries, and modulate synaptic transmission and plasticity.

  • How are human astrocytes typically obtained and cultured for research purposes?

    Human astrocytes can be obtained from post-mortem brain samples or derived from stem cells. They are cultured in specialized media containing essential nutrients and growth factors to support their growth and functionality.

  • What are the main applications of human astrocytes in scientific research?

    Human astrocytes are used in research on neurodevelopment, neurodegeneration, brain injury, and neuroinflammation. They help study diseases like Alzheimer’s, Parkinson’s, and multiple sclerosis, and are used to test the effects of drugs and toxins on the brain.

  • What are the key characteristics when culturing human astrocytes?

    Key characteristics of human astrocytes in culture include their star-shaped morphology, expression of specific markers like GFAP (glial fibrillary acidic protein), and their ability to support neuronal health and function. They should exhibit healthy growth patterns, proper cell-to-cell interactions, and responsiveness to experimental conditions such as changes in media composition or the introduction of pharmacological agents.

  • What are the main challenges in culturing and experimenting with human astrocytes?

    Challenges include keeping the cells alive and functional in vitro, replicating the complex brain environment, and preventing contamination. Variability between samples and the potential for astrocytes to become reactive under stress can also complicate experiments.

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